Manzanola, Colorado has a Cold Semi-Arid Climate climate (Köppen classification: BSk). Average annual temperatures range from 2.4 °C (low) to 20.9 °C (high). Annual precipitation averages 301 Millimeters. Manzanola is located in USDA Plant Hardiness Zone 5b. The growing season typically runs from the last frost around Apr. 21 - Apr. 30 through the first frost around Oct. 1 - Oct. 10.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | -9.8 °C | 8.4 °C | 6.35 mm |
| February | -7.8 °C | 10.2 °C | 6.86 mm |
| March | -3.3 °C | 16.1 °C | 17.53 mm |
| April | 1.4 °C | 20 °C | 32.26 mm |
| May | 7.3 °C | 25.2 °C | 40.39 mm |
| June | 13.2 °C | 31.4 °C | 37.34 mm |
| July | 15.9 °C | 34 °C | 52.07 mm |
| August | 14.9 °C | 32.6 °C | 49.78 mm |
| September | 9.7 °C | 28.8 °C | 18.03 mm |
| October | 1.9 °C | 21.6 °C | 22.35 mm |
| November | -4.7 °C | 14.2 °C | 9.91 mm |
| December | -9.5 °C | 8.4 °C | 8.13 mm |
| Annual | 2.4 °C | 20.9 °C | 301 mm |
| Average First Frost Date | Oct. 1 - Oct. 10 |
| Average Last Frost Date | Apr. 21 - Apr. 30 |
| Average Days With Frost | 150-180 Days |
| Plant Hardiness Zone | Zone 5b : -26.1°C to -23.3°C |
| Plant Hardiness Zone - 2012 | Zone 5b : -26.1°C to -23.3°C |
| Current Drought Conditions | Severe Drought |
| Köppen Climate Classification | BSk - Cold Semi-Arid Climate |