Manasota Key, Florida has a Humid Subtropical Climate climate (Köppen classification: Cfa). Average annual temperatures range from 19 °C (low) to 26.8 °C (high). Annual precipitation averages 1309.9 Millimeters. Manasota Key is located in USDA Plant Hardiness Zone 10b.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | 12.1 °C | 21.2 °C | 70.36 mm |
| February | 13.5 °C | 22.1 °C | 57.15 mm |
| March | 15.4 °C | 23.7 °C | 83.31 mm |
| April | 18.2 °C | 26.1 °C | 66.55 mm |
| May | 21.1 °C | 28.6 °C | 77.22 mm |
| June | 23.6 °C | 30.3 °C | 179.07 mm |
| July | 24.3 °C | 31.2 °C | 195.33 mm |
| August | 24.6 °C | 31.3 °C | 215.39 mm |
| September | 23.7 °C | 30.7 °C | 181.36 mm |
| October | 21.1 °C | 28.7 °C | 82.8 mm |
| November | 16.7 °C | 25.1 °C | 44.2 mm |
| December | 14.1 °C | 22.7 °C | 57.15 mm |
| Annual | 19 °C | 26.8 °C | 1309.89 mm |
| Average First Frost Date | No Frost |
| Average Last Frost Date | |
| Average Days With Frost | Frost Free |
| Plant Hardiness Zone | Zone 10b : 1.7°C to 4.4°C |
| Plant Hardiness Zone - 2012 | Zone 10a : -1.1°C to 1.7°C |
| Current Drought Conditions | Normal |
| Köppen Climate Classification | Cfa - Humid Subtropical Climate |