Mayo, Florida has a Humid Subtropical Climate climate (Köppen classification: Cfa). Average annual temperatures range from 13.9 °C (low) to 26.7 °C (high). Annual precipitation averages 1369.8 Millimeters. Mayo is located in USDA Plant Hardiness Zone 9a. The growing season typically runs from the last frost around Mar. 1 - Mar. 10 through the first frost around Nov. 21 - Nov. 30.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | 4.9 °C | 18.6 °C | 116.33 mm |
| February | 6.4 °C | 20.5 °C | 85.6 mm |
| March | 9.2 °C | 23.8 °C | 108.71 mm |
| April | 12.8 °C | 26.9 °C | 76.96 mm |
| May | 16.9 °C | 30.6 °C | 79.76 mm |
| June | 21.1 °C | 32.4 °C | 175.01 mm |
| July | 22.2 °C | 33 °C | 187.96 mm |
| August | 22.3 °C | 32.7 °C | 195.83 mm |
| September | 20.3 °C | 31.4 °C | 133.6 mm |
| October | 14.9 °C | 27.8 °C | 74.17 mm |
| November | 9.2 °C | 23.3 °C | 52.07 mm |
| December | 6.4 °C | 19.9 °C | 83.82 mm |
| Annual | 13.9 °C | 26.7 °C | 1369.82 mm |
| Average First Frost Date | Nov. 21 - Nov. 30 |
| Average Last Frost Date | Mar. 1 - Mar. 10 |
| Average Days With Frost | 20-30 Days |
| Plant Hardiness Zone | Zone 9a : -6.7°C to -3.9°C |
| Plant Hardiness Zone - 2012 | Zone 8b : -9.4°C to -6.7°C |
| Current Drought Conditions | Extreme Drought |
| Köppen Climate Classification | Cfa - Humid Subtropical Climate |