East Prairie, Missouri has a Humid Subtropical Climate climate (Köppen classification: Cfa). Average annual temperatures range from 9.2 °C (low) to 20.4 °C (high). Annual precipitation averages 1292.9 Millimeters. East Prairie is located in USDA Plant Hardiness Zone 7b. The growing season typically runs from the last frost around Mar. 21 - Mar. 31 through the first frost around Oct. 21 - Oct. 31.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | -2.5 °C | 6.5 °C | 95.76 mm |
| February | -1 °C | 9.2 °C | 101.6 mm |
| March | 3.6 °C | 14.7 °C | 120.65 mm |
| April | 8.9 °C | 20.9 °C | 135.13 mm |
| May | 14.7 °C | 25.9 °C | 139.7 mm |
| June | 19.3 °C | 30.6 °C | 101.6 mm |
| July | 21.1 °C | 32.1 °C | 105.66 mm |
| August | 19.8 °C | 31.5 °C | 74.93 mm |
| September | 15.3 °C | 28.2 °C | 87.63 mm |
| October | 8.8 °C | 22.2 °C | 101.35 mm |
| November | 3.2 °C | 14.5 °C | 111.25 mm |
| December | -0.8 °C | 8.3 °C | 117.6 mm |
| Annual | 9.2 °C | 20.4 °C | 1292.86 mm |
| Average First Frost Date | Oct. 21 - Oct. 31 |
| Average Last Frost Date | Mar. 21 - Mar. 31 |
| Average Days With Frost | 75-100 Days |
| Plant Hardiness Zone | Zone 7b : -15°C to -12.2°C |
| Plant Hardiness Zone - 2012 | Zone 7a : -17.8°C to -15°C |
| Current Drought Conditions | Normal |
| Köppen Climate Classification | Cfa - Humid Subtropical Climate |