Greenville, Missouri has a Humid Subtropical Climate climate (Köppen classification: Cfa). Average annual temperatures range from 7.4 °C (low) to 20.1 °C (high). Annual precipitation averages 1239.3 Millimeters. Greenville is located in USDA Plant Hardiness Zone 7a. The growing season typically runs from the last frost around Apr. 1 - Apr. 10 through the first frost around Nov. 1 - Nov. 10.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | -4.7 °C | 6.6 °C | 82.55 mm |
| February | -2.9 °C | 9.4 °C | 83.06 mm |
| March | 1.6 °C | 14.9 °C | 109.73 mm |
| April | 6.9 °C | 21.3 °C | 136.14 mm |
| May | 12.5 °C | 25.3 °C | 137.16 mm |
| June | 17.2 °C | 29.8 °C | 90.17 mm |
| July | 19.6 °C | 31.4 °C | 118.62 mm |
| August | 18.4 °C | 31.2 °C | 86.11 mm |
| September | 13.8 °C | 27.7 °C | 89.15 mm |
| October | 7.2 °C | 21.7 °C | 91.19 mm |
| November | 1.5 °C | 14.3 °C | 115.32 mm |
| December | -2.8 °C | 8.1 °C | 100.08 mm |
| Annual | 7.4 °C | 20.1 °C | 1239.28 mm |
| Average First Frost Date | Nov. 1 - Nov. 10 |
| Average Last Frost Date | Apr. 1 - Apr. 10 |
| Average Days With Frost | 75-100 Days |
| Plant Hardiness Zone | Zone 7a : -17.8°C to -15°C |
| Plant Hardiness Zone - 2012 | Zone 6b : -20.6°C to -17.8°C |
| Current Drought Conditions | Normal |
| Köppen Climate Classification | Cfa - Humid Subtropical Climate |