Puxico, Missouri has a Humid Subtropical Climate climate (Köppen classification: Cfa). Average annual temperatures range from 8.6 °C (low) to 20.3 °C (high). Annual precipitation averages 1311.7 Millimeters. Puxico is located in USDA Plant Hardiness Zone 7a. The growing season typically runs from the last frost around Mar. 21 - Mar. 31 through the first frost around Nov. 1 - Nov. 10.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | -3.6 °C | 6.3 °C | 91.44 mm |
| February | -1.8 °C | 9.2 °C | 90.68 mm |
| March | 2.7 °C | 14.7 °C | 123.95 mm |
| April | 8.2 °C | 21 °C | 148.08 mm |
| May | 13.9 °C | 25.8 °C | 138.94 mm |
| June | 18.8 °C | 30.4 °C | 95 mm |
| July | 20.8 °C | 31.9 °C | 116.59 mm |
| August | 19.6 °C | 31.5 °C | 83.57 mm |
| September | 15.1 °C | 28.1 °C | 86.36 mm |
| October | 8.4 °C | 22.1 °C | 106.93 mm |
| November | 2.6 °C | 14.3 °C | 121.41 mm |
| December | -1.7 °C | 8.1 °C | 108.71 mm |
| Annual | 8.6 °C | 20.3 °C | 1311.66 mm |
| Average First Frost Date | Nov. 1 - Nov. 10 |
| Average Last Frost Date | Mar. 21 - Mar. 31 |
| Average Days With Frost | 75-100 Days |
| Plant Hardiness Zone | Zone 7a : -17.8°C to -15°C |
| Plant Hardiness Zone - 2012 | Zone 6b : -20.6°C to -17.8°C |
| Current Drought Conditions | Abnormally Dry |
| Köppen Climate Classification | Cfa - Humid Subtropical Climate |