Lisco, Nebraska has a Cold Semi-Arid Climate climate (Köppen classification: BSk). Average annual temperatures range from 1.4 °C (low) to 17.8 °C (high). Annual precipitation averages 462.3 Millimeters. Lisco is located in USDA Plant Hardiness Zone 5a. The growing season typically runs from the last frost around May 1 - May 10 through the first frost around Sep. 21 - Sep. 30.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | -10.8 °C | 4.6 °C | 8.89 mm |
| February | -9.2 °C | 6.6 °C | 12.45 mm |
| March | -4.5 °C | 12.4 °C | 24.38 mm |
| April | 0.3 °C | 16.8 °C | 54.36 mm |
| May | 6.3 °C | 21.7 °C | 76.96 mm |
| June | 12.1 °C | 28.3 °C | 74.42 mm |
| July | 15.4 °C | 31.9 °C | 63.25 mm |
| August | 14.2 °C | 30.7 °C | 47.5 mm |
| September | 8.4 °C | 26.2 °C | 41.15 mm |
| October | 0.7 °C | 18.2 °C | 32 mm |
| November | -5.7 °C | 11.1 °C | 14.22 mm |
| December | -10.4 °C | 4.9 °C | 12.7 mm |
| Annual | 1.4 °C | 17.8 °C | 462.28 mm |
| Average First Frost Date | Sep. 21 - Sep. 30 |
| Average Last Frost Date | May 1 - May 10 |
| Average Days With Frost | 150-180 Days |
| Plant Hardiness Zone | Zone 5a : -28.9°C to -26.1°C |
| Plant Hardiness Zone - 2012 | Zone 5a : -28.9°C to -26.1°C |
| Current Drought Conditions | Exceptional Drought |
| Köppen Climate Classification | BSk - Cold Semi-Arid Climate |