Keyes, Oklahoma has a Cold Semi-Arid Climate climate (Köppen classification: BSk). Average annual temperatures range from 4.5 °C (low) to 21.3 °C (high). Annual precipitation averages 436.9 Millimeters. Keyes is located in USDA Plant Hardiness Zone 6b. The growing season typically runs from the last frost around Apr. 21 - Apr. 30 through the first frost around Oct. 11 - Oct. 20.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | -6.8 °C | 9.5 °C | 9.4 mm |
| February | -5.7 °C | 11.2 °C | 7.87 mm |
| March | -1.6 °C | 16.1 °C | 24.13 mm |
| April | 2.8 °C | 20.4 °C | 33.78 mm |
| May | 8.6 °C | 25.8 °C | 50.55 mm |
| June | 14.5 °C | 31.5 °C | 61.72 mm |
| July | 17.4 °C | 33.8 °C | 71.12 mm |
| August | 16.5 °C | 32.3 °C | 77.47 mm |
| September | 12 °C | 28.7 °C | 35.31 mm |
| October | 4.6 °C | 22 °C | 39.37 mm |
| November | -1.9 °C | 15.1 °C | 11.94 mm |
| December | -6.4 °C | 9.3 °C | 14.22 mm |
| Annual | 4.5 °C | 21.3 °C | 436.88 mm |
| Average First Frost Date | Oct. 11 - Oct. 20 |
| Average Last Frost Date | Apr. 21 - Apr. 30 |
| Average Days With Frost | 125-150 Days |
| Plant Hardiness Zone | Zone 6b : -20.6°C to -17.8°C |
| Plant Hardiness Zone - 2012 | Zone 6b : -20.6°C to -17.8°C |
| Current Drought Conditions | Extreme Drought |
| Köppen Climate Classification | BSk - Cold Semi-Arid Climate |