East Prairie, Missouri has a Humid Subtropical Climate climate (Köppen classification: Cfa). Average annual temperatures range from 48.6 °F (low) to 68.7 °F (high). Annual precipitation averages 50.9 Inches. East Prairie is located in USDA Plant Hardiness Zone 7b. The growing season typically runs from the last frost around Mar. 21 - Mar. 31 through the first frost around Oct. 21 - Oct. 31.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | 27.5 °F | 43.7 °F | 3.77 in. |
| February | 30.2 °F | 48.6 °F | 4.0 in. |
| March | 38.4 °F | 58.5 °F | 4.75 in. |
| April | 48.1 °F | 69.6 °F | 5.32 in. |
| May | 58.5 °F | 78.7 °F | 5.5 in. |
| June | 66.7 °F | 87.0 °F | 4.0 in. |
| July | 70.0 °F | 89.7 °F | 4.16 in. |
| August | 67.7 °F | 88.7 °F | 2.95 in. |
| September | 59.6 °F | 82.8 °F | 3.45 in. |
| October | 47.9 °F | 71.9 °F | 3.99 in. |
| November | 37.8 °F | 58.1 °F | 4.38 in. |
| December | 30.6 °F | 46.9 °F | 4.63 in. |
| Annual | 48.6 °F | 68.7 °F | 50.9 in. |
| Average First Frost Date | Oct. 21 - Oct. 31 |
| Average Last Frost Date | Mar. 21 - Mar. 31 |
| Average Days With Frost | 75-100 Days |
| Plant Hardiness Zone | Zone 7b : 5°F to 10°F |
| Plant Hardiness Zone - 2012 | Zone 7a : 0°F to 5°F |
| Current Drought Conditions | Moderate Drought |
| Köppen Climate Classification | Cfa - Humid Subtropical Climate |