Greenville, Missouri has a Humid Subtropical Climate climate (Köppen classification: Cfa). Average annual temperatures range from 45.2 °F (low) to 68.3 °F (high). Annual precipitation averages 48.8 Inches. Greenville is located in USDA Plant Hardiness Zone 7a. The growing season typically runs from the last frost around Apr. 1 - Apr. 10 through the first frost around Nov. 1 - Nov. 10.
| Month | Avg. Low | Avg. High | Avg. Precip |
|---|---|---|---|
| January | 23.5 °F | 43.8 °F | 3.25 in. |
| February | 26.8 °F | 49.0 °F | 3.27 in. |
| March | 34.9 °F | 58.8 °F | 4.32 in. |
| April | 44.5 °F | 70.4 °F | 5.36 in. |
| May | 54.5 °F | 77.6 °F | 5.4 in. |
| June | 63.0 °F | 85.6 °F | 3.55 in. |
| July | 67.2 °F | 88.6 °F | 4.67 in. |
| August | 65.1 °F | 88.1 °F | 3.39 in. |
| September | 56.9 °F | 81.9 °F | 3.51 in. |
| October | 44.9 °F | 71.1 °F | 3.59 in. |
| November | 34.7 °F | 57.8 °F | 4.54 in. |
| December | 26.9 °F | 46.6 °F | 3.94 in. |
| Annual | 45.2 °F | 68.3 °F | 48.79 in. |
| Average First Frost Date | Nov. 1 - Nov. 10 |
| Average Last Frost Date | Apr. 1 - Apr. 10 |
| Average Days With Frost | 75-100 Days |
| Plant Hardiness Zone | Zone 7a : 0°F to 5°F |
| Plant Hardiness Zone - 2012 | Zone 6b : -5°F to 0°F |
| Current Drought Conditions | Moderate Drought |
| Köppen Climate Classification | Cfa - Humid Subtropical Climate |